1. Research on metabolic signal pathway in cardiovascular and metabolic diseases. Metabolism is closely related to the cardiovascular and metabolic diseases. The development and prognosis of cardiovascular and metabolic diseases have metabolic signal pathway participation. Metabolic regulation is an important regulation of pathophysiological process of cardiovascular and metabolic diseases. Our team has discovered some of the new pathophysiological mechanisms and clinical relevance on metabolic molecules and related regulating proteins, including the metabolic signaling pathways such as succinic acid metabolism, lipid metabolism, and amino acid metabolism in cardiovascular and metabolic diseases.
2. Intestinal flora metabolism in cardiovascular and metabolic diseases. The intestinal flora is a complex system which can affect cardiovascular and metabolic diseases. Intestinal flora is an important source for metabolites. Due to the existence of these metabolites, it affects other organs, such as cardiovascular and metabolic systems. Our team discovered the new intestinal flora metabolites such as TMAVA (trimethyl-5-aminovaleric acid) on the pathological and physiological effects of the heart and the liver, and also found the new pathophysiology effects of TMAO (trimethylamine oxide) that has been well known as a metabolite from intestinal flora.
3. Combining new materials and new technologies to carry out translational medicine research in cardiovascular diseases. Translational medicine research includes the diagnosis and treatment method of cardiovascular disease. Applying nano-technology and probe materials to the diagnosis and treatment of cardiovascular diseases. Targeting inflammatory cells such as macrophage and foam cell, we use nano-technology to conduct diagnosis and treatment application. Also, using mass spectrometry technology allow us to perform new diagnostic method in the diagnosis and prognosis of cardiovascular and metabolic diseases.