1. Research on metabolic signal pathway in cardiovascular and metabolic diseases. Metabolism is closely related to the cardiovascular and metabolic diseases. The development and prognosis of cardiovascular and metabolic diseases have metabolic signal pathway participation. Metabolic regulation is an important regulation of pathophysiological process of cardiovascular and metabolic diseases. Our team has discovered some of the new pathophysiological mechanisms and clinical relevance on metabolic molecules and related regulating proteins, including the metabolic signaling pathways such as succinic acid metabolism, lipid metabolism, and amino acid metabolism in cardiovascular and metabolic diseases.
2. Intestinal flora metabolism in cardiovascular and metabolic diseases. The
intestinal flora is a complex system which can affect cardiovascular and metabolic
diseases. Intestinal flora is an important source for metabolites. Due to the
existence of these metabolites, it affects other organs, such as cardiovascular
and metabolic systems. Our team discovered the new intestinal flora metabolites
such as TMAVA (trimethyl-5-aminovaleric acid) on the pathological and
physiological effects of the heart and the liver, and also found the new pathophysiology
effects of TMAO (trimethylamine oxide) that has been well known as a metabolite
from intestinal flora.
3. Combining new materials and new technologies to carry out translational
medicine research in cardiovascular diseases. Translational medicine research
includes the diagnosis and treatment method of cardiovascular disease. Applying
nano-technology and probe materials to the diagnosis and treatment of
cardiovascular diseases. Targeting inflammatory cells such as macrophage and
foam cell, we use nano-technology to conduct diagnosis and treatment
application. Also, using mass spectrometry technology allow us to perform new
diagnostic method in the diagnosis and prognosis of cardiovascular and metabolic
diseases.
Lemin Lab